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16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione
Basic Information
- CAS No.: 51372-29-3
Physical properties
Product Description
Reputable factory supply 16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione 51372-29-3 in stock with high standard
- Molecular Formula: C25H34O6
- Molecular Weight: 430.541
- Appearance/Colour: light beige solid
- Melting Point: 194-199 °C
- Boiling Point: 599.7 °C at 760 mmHg
- PKA: 12.87±0.10(Predicted)
- Flash Point: 201.8 °C
- PSA： 93.06000
- Density: 1.27 g/cm3
- LogP: 2.71680
16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione(Cas 51372-29-3) Usage
InChI:InChI=1/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21+,22+,23-,24-,25+/m0/s1
51372-29-3 Relevant articles
Preparation method of budesonide
-
Paragraph 0032; 0037-0038; 0043-0044; 0049, (2020/09/01)
The invention discloses a preparation me...
A budesonide industrial preparation method (by machine translation)
-
Paragraph 0039; 0048-0051, (2019/03/10)
The invention relates to a cloth budeson...
INDUSTRIAL ECOLOGICAL PROCESS OF MANUFACTURING OF BUDESONIDE
-
Page/Page column 6; 7; 8; 9; 10; 11; 12, (2018/03/09)
Disclosed herein is an improved process ...
A preparation method of budesonide
-
Paragraph 0064; 0065; 0066; 0074, (2017/08/25)
The invention discloses a budesonide pre...
51372-29-3 Process route
-
![2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate](/upload/2026/4/2f1446704cbc4168b9b816153ed87335_e1268ce9-3dcd-49f1-908d-fd3ce4384794.png)
-
51333-05-2
2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
-
-
51372-29-3
budesonide
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
ethanol;
at 0 - 5 ℃;
for 3.5h;
pH=8 - 9;
Solvent;
|
83.1%
|
|
With
methanol; triethylamine;
for 0.166667h;
Ambient temperature;
Irradiation;
|
99 % Chromat.
|
|
With
potassium hydroxide;
In
methanol; dichloromethane;
at -5 - 0 ℃;
for 1.16667h;
|
8.5 g
|
-
-
13951-70-7
desonide
-
-
123-72-8
butyraldehyde
-
-
51372-29-3
budesonide
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
dichloromethane; water; acetonitrile;
at 20 ℃;
for 1h;
|
95%
|
|
With
phosphoric acid;
at 0 - 5 ℃;
for 4 - 4.5h;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride;
In
water;
at 0 - 5 ℃;
for 2.66667h;
Product distribution / selectivity;
Inert atmosphere;
|
|
|
With
perchloric acid;
In
1,4-dioxane; water;
at 0 ℃;
Solvent;
Inert atmosphere;
|
773 g
|
|
With
benzenesulfonic acid;
In
tetrahydrofuran;
at 45 ℃;
Reagent/catalyst;
Solvent;
Temperature;
|
30.9 g
|
51372-29-3 Upstream products
-
51333-05-2
2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
-
13951-70-7
desonide
-
123-72-8
butyraldehyde
-
638-94-8
desonide
51372-29-3 Downstream products
-
51372-28-2
(22S)-Budesonide
-
51333-05-2
2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate